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Thursday, July 18, 2013


 TA 65 is in battling free radicals

I am not sure how many times I’ve said that longer telomeres protect against cancer. Probably almost as many times as I’ve had to refute someone saying “telomerase causes cancer therefore TA-65 might cause cancer.”
Back in December 2010 JAMA a very drug centric Big Pharma supported journal published a study that associated short telomere lengths with more cancer and worse cancer and vice versa. Conclusion: short telomeres are associated with cancer and long ones are not.  Then came the attacks
“What about those tumors that have longer telomeres like glioblastoma?”
Answer: those tumors use the ALT mechanism to lengthen their telomeres which does not involve telomerase. This mechanism, ALT, is however associated with the same genetic (or if you prefer genomic) instability that is caused by short telomeres because the recombination of ALT ruins the integrity of the genome, similar to the way short telomeres allow the genome to become unstable.
The common pathway is genome instability.
So over the past 5 years or so I’ve been fighting a slowly winning battle to convince more and more people that having longer telomeres Readon...